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Not into muscle

Nonetheless, insulin/IGF signaling has been demonstrated to attenuate inflammatory responses, e.g., in human myocardial infarction [21] and severe thermal trauma [22] as well as in many mouse models, such as colitis [23], vascular inflammation [24], IL-1-induced cartilage degradation [25], lipopolysaccharide-provoked brain injuries [26], and experimental multiple sclerosis and autoimmune diabetes [27, 28]

Randomization and blinding Participants were randomized into three intervention groups in a 1:1:1 ratio (14 subjects per group) using block randomization by an unblinded person not involved in study assessments

Collectively, the metabolic flexibility provided by glutamine and arginine supports both the bioenergetic and biosynthetic needs of fibrotic tissues while sustaining a permissive microenvironment for chronic immune dysregulation and fibroblast persistence