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They reduce de novo lipogenesis by inhibiting transcription factor sterol regulatory element-binding protein 1c (SREBP-1c), which is a master regulator of fatty acid synthesis (Shantaram et al., 2025

Semaglutide cons Side effects : The main drawbacks of semaglutide are possible stomach-related side effects like nausea, diarrhea and vomiting, which can be bothersome for some people