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Additionally, a recent real-world study reported greater weight loss with tirzepatide than with semaglutide in overweight or obese patients [7], which further supports the trends noted in our study

This can have a positive impact on weight management, given the weight-gain-associated side effect of insulin therapy

Some patients lose substantially more, while others lose less or discontinue treatment because of side effects, cost, access, or inadequate response

From these data, we conclude that GLP-1R is involved in regulating TNC microglial activation during NTG injection, and this function of GLP-1R might also be the mechanism for attenuating CM-related allodynia