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Notably, senkyunolides, core bioactive compounds derived from traditional anti-migraine herbs like Ligusticum chuanxiong , have emerged as promising candidates due to the role of multidimensional homeostasis in regulating neurovascular units (suppressing activation of the trigeminal vascular system, modulating pathological vascular alterations, modulating neurotransmitters and receptors, inhibiting inflammatory response, antioxidant stress and analgesic effects and improving blood-brain barrier integrity) and unique pharmacokinetic advantages (small-molecule structure enabling blood-brain barrier penetration, natural origin reducing hepatorenal toxicity risks)
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Aliquots containing 100 g of proteins were subjected to reductive alkylation, incubated with 10 mM dithiothreitol for 40 min at room temperature, which was followed by the addition of 50 mM iodoacetamide and a 40 min incubation at room temperature in the dark
Finally, equity concerns matter
Wharton S, Lau DCW, Vallis M, et al
