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In the STEP 1 trial , 1,961 adults with a BMI of 30 or higher (or 27 with weight-related health conditions) took weekly doses of Semaglutide 2.4 mg for 68 weeks

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The precursor literature includes human pharmacokinetic work

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The experts believe that the complementary rather than synergistic mechanisms of action make it unlikely that the well-known class effects of GLP1-RAs and SGLT2is will differ in combination