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Studies have found that in the retinal tissue of DR patients, high glucose can induce upregulation of NCOA4 expression, enhance ferritinophagy, reduce FtL, increase LC3-II/I, and activate NOX to produce ROS, forming a ROS ferritinophagy-free iron positive feedback loop (172)
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The phase 2 combination trial in type 2 diabetes Frias et al
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In some more particular embodiments, the maximum plasma concentration ((Cmax)E) of the therapeutic agent in systemic circulation versus time is at least about 15% of the AUC obtained when the same amount of the therapeutic agent is delivered subcutaneously ((C max ) SC )
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