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Due to this effect, patients are able to take GLP1R agonists, when paired with these compounds, at higher doses without the side effects becoming too severe (increasing therapeutic efficacy)
While this usually subsides, it raises a valid question: Are people losing weight because their metabolism is optimized, or because they feel too sick to eat
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The mice also showed signs of GLP-1 resistance: elevated levels of GLP-1 that did not help regulate blood sugar
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