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As demand for GLP-1 medications surges, one key detail is often overlooked: the body is already equipped with this powerful hormone

It can be found in your skeletal system, heart, muscle cells and brainalthough most of it is found in your muscles

Contact your GP if tiredness persists beyond 46 weeks, significantly impairs daily activities, is accompanied by frequent hypoglycaemia, signs of dehydration, unexplained weight loss, mood changes, or symptoms suggesting sleep apnoea such as excessive daytime sleepiness

For a broader endocrine ranking that separates GH-axis peptides from HPG-axis compounds, see our best peptides for testosterone guide

And a study published in January 2025 suggested that popular GLP-1 medications approved for weight loss, diabetes and heart disease may have untapped potential to reduce the risks of substance abuse disorders, psychosis, infections and some kinds of cancer and dementia