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Description

Whilst not explored in detail in the latter project, we observed that the addition of a C-terminal acyl chain further influenced the ability of each ligand to recruit G proteins and -arrestins to the GLP-1R, highlighting this feature as a modifier of GLP-1R efficacy in its own right

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Measurement of the NF-B activation in our in vivo experiment showed that GHK-Cu blocked the transcriptional activity of NF-B through suppression of NF-B by altering the phosphorylation of its inhibitor i-B

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