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Levels of active G6PD are regulated at both the transcriptional level via various canonical signaling pathways (e.g., JAK-STAT, Wnt, mTOR), and at the post-translational level (e.g., via phosphorylation, de-acetylation), allowing tight coordination of G6PD activity to meet acute cellular demand in response to oxidative stress, metabolic demand, or systemic inflammation ( Figure 1A-1 )

Male C57Bl/6 mice (Charles River, UK) were fed a 60% high fat diet (D12492, Research Diets, USA) for 3 months prior to the study to induce obesity and glucose intolerance

No, GLP-1 receptor agonists do not impair pancreatic enzyme production or secretion

Vitamin C is considered an antioxidant

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