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The FDA has approved multiple medications targeting incretin pathways, categorized into GLP-1 receptor agonists and the dual GIP/GLP-1 receptor agonist
Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism
GLP-1 medications include semaglutide, dulaglutide, and liraglutide, used for type 2 diabetes and weight management Common gastrointestinal effects (nausea, vomiting, diarrhoea) can lead to fluid loss and electrolyte depletion affecting muscle function Maintaining adequate hydration (1.52 litres daily) and dietary electrolyte intake may help prevent cramping Concurrent medications such as diuretics, SGLT2 inhibitors, and statins may contribute to muscle-related symptoms Persistent, severe, or frequent cramps warrant medical review to assess electrolytes, renal function, and exclude other causes Table of Contents What Are GLP-1 Medications and How Do They Work
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