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[1] [2] As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide works by enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying
However, while potent, semaglutide often comes with a host of commonbut usually mildside effects
The EMAs safety committee has issued a warning that the GLP-1 receptor agonist Ozempic (semaglutide, Novo Nordisk A/S) can cause an acute eye condition in which the optic nerve is damaged by a sudden loss of blood supply
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Future studies should also explore the brain-circuit connectivity between LS GLP-1R/GIPR pathways and other regions since this could clarify which specific neural circuits contribute to tirzepatides effects on reward processing and alcohol consumption
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