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Pediatrics, 108(3), 776-789

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2-tert-butyl-5-pyrrolidin-1-yl-1,3,4-thiadiazole 4 2 1 H NMR (500 MHz, MeOD): 3.44-3.47 (4H, m), 2.05-2.08 (4H, m), 1.30 (9H, s)

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A study using a chemotherapeutic sensitivity assay and flow cytometry (FCM) to analyze the relationship between HIF-1 expression and sensitivity to chemotherapy revealed that HIF-1 inhibition reversed MDR in colon cancer cells via the downregulation of MDR1/P-gp [26]