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doi: 10.1016/j.annonc.2023.04.002 146 SehgalAHodaDRiedellPAGhoshNHamadaniMHildebrandtGCet al
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In contrast to GSH synthesis, which occurs intracellularly, GSH degradation occurs exclusively in the extracellular space, and in particular, on the surface of cells that express the enzyme -glutamyl transpeptidase (also called -glutamyl transferase, GGT
Human data remain limited to case reports, so efficacy in clinical practice is still under evaluation
Patients frequently report prolonged recovery times after physical exertion, degraded sleep architecture, thinning skin, osteopenia, and a generalized reduction in vitality
Increasing dose may not solve the core issue if absorption is inconsistent
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