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Every protocol you see, whether from a doctor, a website, or a study, is an educated guess based on animal data or trial-and-error

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The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

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Methotrexate and its mechanisms of action in inflammatory arthritis

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