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The modification at N-glycosylation sites N40, N72, and N88 is essential for ZIP8-mediated intracellular iron accumulation, which further results in elevated LPO and subsequent RPE cell death[186]

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doi: 10.1210/endo.139.4.5921 48 NauckMABartelsEOrskovCEbertRCreutzfeldtW