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196 For people who are unable to attain weight-related health improvements with behaviour modifications and pharmacotherapy, or unable to sustain weight loss after treatment discontinuation, referral to specialised care is generally required

As they are highly reactive, ROS can react with and damage important molecules, such as DNA , lipids (such as those in cell membranes) and proteins (including key enzymes and structural proteins)

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The hormone was first identified in the 1980s when researchers discovered that oral glucose intake stimulated more insulin release than intravenous glucose administration, a phenomenon known as the incretin effect

Tranexamic acid can also be taken orally for more severe cases of hyperpigmentation, or administered through an intradermal injection