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Oral semaglutide is taken once daily and reduces HbA 1c levels to a significantly higher extent than DPP-4 inhibition or sodiumglucose cotransporter 2 (SGLT-2) inhibition and to a similar extent as liraglutide, whereas body weight is reduced by a significantly higher extent than by DPP-4 inhibition and liraglutide and to a similar extent as SGLT-2 inhibition [30, 31]
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Nutr Neurosci
This has resulted in the prevalence of studies with correlation, but causation is still uncertain
Rat studies have noted embryofetal mortality, structural abnormalities, and alterations to growth at maternal exposures below the maximum recommended human dose (MRHD) based on exposure AUC
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