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2024 Feb 19;69:102475

Y., Vanzin, C

Cardiovascular-Kidney-Metabolic (CKM) Syndrome , as defined by the AHA, is a systemic disorder characterized by pathophysiological interactions among metabolic risk factors (such as obesity, insulin resistance, dyslipidemia, and hypertension), chronic kidney disease (CKD), and the cardiovascular system, leading to multiorgan dysfunction and a high rate of adverse cardiovascular outcomes [145]

Scaffold-based methods introduce a porous matrixnatural (collagen, gelatin, fibronectin) or synthetic (PLGA)to direct cell survival and vessel ingrowth, which can mitigate early necrosis but complicate manufacture and regulatory review