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Indeed, elevated plasma TMAO levels may increase the risk of atherosclerotic cardiovascular disease (ASCVD) (Yang et al., 2019

Critically, the peptide showed therapeutic efficacy even when administered after neurotoxin exposure

Long-term unknowns: Continuous use has not been studied thoroughly, so long-term daily protocols should be approached with caution

a single receptor may recognize multiple PRLMs, and conversely, one PRLMs can activate more than one receptor