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In patients with T2D uncontrolled with metformin (with or without sulfonylurea) (PIONEER 3), oral semaglutide (7 and 14 mg) significantly reduced HbA 1c versus sitagliptin 100 mg (ETD: 0.3% and 0.5%, respectively

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Bowel perforation , which can lead to peritonitis (a life-threatening infection)

While each medication has its own side effect profile, their concurrent use may create additive or synergistic risks