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In vivo, in conscious swine a model with GH axis pharmacology closely reflective of human GH secretion ipamorelin produced an ED50 of 2.3 0.03 nmol/kg and an Emax of 65 0.2 ng GH/mL plasma, comparable to GHRP-6 (ED50 3.9 1.4 nmol/kg, Emax 74 7 ng/mL) but with substantially superior selectivity

Mitochondrial dynamics and inheritance during cell division, development and disease

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For example, the TUNEL assay, which detects DNA strand breaks [47], stains necrotic cells during APAP hepatotoxicity [42, 48]