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The secretions of TNF and IL-6, the priming agents regulating the entry into G1 phase, were delayed leading to a postponed induction of the immediate-early genes such as c-Fos and Jun-B as well as a late and reduced activation of STAT3
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Safety also requires attention, especially hypercalcemia and mineral imbalance with active agents or bolus regimens
FOXO4-DRI is an investigational compound with no completed or registered human clinical trials
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