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Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig
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This detoxification process primarily occurs in the liver, where GSH binds to foreign compounds
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6.2 Thioredoxin Structure The TRX active site contains a conserved sequence (CysGlyProCys) and belongs to a TRX superfamily, in which all members share similar active site sequences CysXYCys)
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