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Adherence to Standard Protocols and the Problem with One-Size-Fits-All Guidelines The Core of the Issue: The primary reason for refusal is that the GP surgery is typically following a strict protocol based on established guidelines

(2) generalized joint hypermobility with or without recurrent dislocations (most commonly shoulder and ankle)

The original mucosal-cytoprotection context

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[5] [6] It should not be used outside of regulated clinical trial settings