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Why this matters for stacking: any peptide or compound that increases monoamine release or prevents their breakdown compounds tesofensine's effect multiplicatively, not additively

doi:10.1016/j.diabres.2021.108899 Fathy MA, Anbaig A, Aljafil R, et al

This happens due to a lack of an intrinsic factor, a protein necessary for B12 absorption in the stomach

This, in turn, stimulates downstream signaling elements dependent on both protein kinase A (PKA) and exchange protein directly activated by cAMP (EPAC) activation, which triggers the opening of voltage-dependent calcium channels (VDCCs), resulting in insulin exocytosis [24, 25]

For example, instead of finishing three slices of pizza, one slice feels enough