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We hypothesized that low glutathione redox status would be associated with elevated markers of oxidative protein and DNA damage, inflammation and mitochondrial superoxide production in two regions that have been reported to be abnormal in autism, cerebellum and BA22
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Caution should be taken with those that have megaloblastic anemia as B12 can reduce potassium levels in the blood
Some observational studies have found a link between low blood levels of folate and higher risk of dementia
Consequently, an extracellular cystine or intracellular cysteine deficiency or inhibition of system ( SLC7A11 ) would reduce the GSH level, inhibit GSH-dependent GPX4 activity, and lead to the intracellular accumulation of L-ROS and cell death (Dolma et al., 2003
