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These factors are produced by selective posttranslational modification of proglucagon , a 160-residue peptide expressed by the -cells of the pancreas, K and L cells of the small intestine

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(A) Metabolites (phosphatidylcholines, sphingomyelins, acylcarnitines) showing differential patterns in the serum of mice aged 2 (n = 2), 4 (n = 3), 14 (n = 2), and 21 months (n = 3)