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Treatment of clozapineassociated obesity and diabetes with exenatide in adults with schizophrenia: a randomized controlled trial (CODEX)
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Here is the breakdown by dose group from the trial: 4 mg dose group: average weight loss of 8.7% 8 mg dose group: average weight loss of 17.3% 12 mg dose group: average weight loss of 24.2% Placebo group: average weight loss of 2.1% The 12 mg group also showed that 26% of participants lost 30% or more of their body weight
Thus, preventing the decline of leptin levels during weight loss by hormone replacement may be a means of overriding the homeostatic and behavioral tendencies toward energy conservation and weight regain during dieting
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