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The steering committee integrated the literature evidence and wrote the graded recommendations and the underlying rationale, graded the strength of the recommendations and developed practice points
Semaglutide Is the Better-Evidenced Agent Several randomized trials conducted between 2021 and 2025 showed semaglutide 1.02.4mg weekly produces roughly 1015% weight loss in PCOS patients over 612 months, with parallel improvements in menstrual cycle frequency, testosterone, sex hormone-binding globulin (SHBG), and HOMA-IR (a marker of insulin resistance)
This personalized approach is one of the key benefits of working with a clinic that compounds GLP-1 medications rather than using commercial formulations
Tia's Perimenopause/Menopause Assessment is the best place to start
Similarly, those prescribed the drug for obesity or overweight were over seven times more likely to receive the same diagnosis
