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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis via the salvage pathway, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility [3]
10.1016/j.tcb.2015.10.014 Trends Cell Biol
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Gastrointestinal symptoms typically improve over time regardless of administration schedule
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