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(6) Increased bone marrow adipose tissue accumulation and altered mesenchymal stem cell differentiation contribute to reduced osteoblast activity, increased osteoclastic resorption, and an overall decline in bone strength, leading to a greater fracture risk despite higher bone mineral density measurements

In various mice and rat inflammation models, mPGES-1 plays a pathogenic role in tumorigenesis (Fahmi, 2003

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Older adults on metformin are among the most likely to be overtly hypomagnesemic

New evidence emerging in 2025 deepens the understanding of how these two compounds, one primarily a local signal modulator and the other a systemic cellular mobilizer, work in tandem to dramatically enhance the speed and quality of bone repair