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Whether loose skin will tighten on its own depends primarily on patient age, how long the skin was stretched, how much weight was lost, and how quickly it happened

The biology is complex, and that GLP-1 receptor in the body is not only controlling one thing or doing one thing, but has an intricate web of various effects. This article is exclusive to STAT+ subscribers Unlock this article plus in-depth analysis, newsletters, premium events, and news alerts

What to expect in your first month on Mounjaro During your first month on Mounjaro, youll likely experience several changes as your body adjusts to the medication: Week 1-2: Initial impact on appetite usually begin within 24-48 hours of your first injection You may notice reduced hunger and food cravings Youll likely feel fuller quicker Side effects like nausea or fatigue may appear (more on managing these below) Week 3-4: Weight loss typically becomes noticeable (2-4% of starting weight) Some people experience the medications effects wearing off 4-5 days after injection Hunger levels become more consistent Side effects generally start to decrease The SURMOUNT-1 trial data 1 shows that while the average weight loss is 2-4% in the first month, the range varies considerably

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After reconstitution for laboratory use, keep cold and use promptly