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Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies

Notably, the control group retained baseline sucrose preference levels, whereas the model group exhibited a significant reduction, underscoring the effect of PCPA

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I would not change the dose again for a week at least

Sustainable weight management is best achieved through a combination of dietary change, physical activity, and behavioural support, with pharmacotherapy used as an adjunct where clinically indicated and in line with NICE guidance