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What Experts Say: Medical professionals emphasize that tirzepatides benefitslike significant weight loss and improved metabolic healthoften outweigh the risks for eligible patients

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Risks and Safety Considerations to Discuss With Your Doctor Combined use may compound individual risks including unpredictable glycaemic fluctuations, fluid retention, nausea, gallbladder complications, and pancreatitis

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In one clinical trial, people who stopped tirzepatide (Zepbound) regained about 14% of their body weight over the following year, while those who continued treatment lost additional weight