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Tesamorelin was developed under the brand name Egrifta and received FDA approval for reducing excess visceral fat in HIV-associated lipodystrophy, making it one of the few GHRH analogs with both clinical trial data and regulatory approval behind it
The research above (Badenhorst, Finkley, Abdulghani, Carey/Pickart) all studied topical application
Following their synthesis, polyamines can be exported from cells following incorporation into secretory vesicles
Adverse event data in humans is sparse
However, despite these benefits, the viscous texture of ophthalmic ointments can cause blurred vision, irritation, and discomfort, which may affect patient compliance, particularly with frequent use [358]
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