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Hyperpigmentation is triggered by sun exposure, inflammation, medications, and genetics, while melasma is usually caused due to hormonal changes

10.1016/j.jbc.2022.101796 8 AldahhanR

To investigate whether increasing the dose could help, Sean Wharton from the University of Toronto in Canada and his colleagues recruited over 1,000 obese adults in 11 countries, including the US, Canada, and parts of Europe