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Moreover, several large-scale clinical trials 6,7,8,9,10 such as LEADER, SUSTAIN-6, and REWIND have demonstrated that GLP-1RAs can reduce the incidence of MACEs in patients with T2D and established cardiovascular disease or high cardiovascular risk
In addition, the use of aggregated data precluded adjustment for exposure time
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The trial results above were obtained with branded semaglutide, not compounded preparations
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