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Pernicious anaemia, atrophic gastritis, proton pump inhibitors, metformin, and gastrointestinal surgery significantly impair B12 absorption
BPC-157: More localized, especially in the GI tract and connective tissue TB-500: Broader systemic effects, influencing cell migration and circulation In some cases, both may be considered together (bpc157 and tb500) as complementary, though decisions must be individualized and physician-guided
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