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Much of the current evidence comes from laboratory and animal studies, which are encouraging but are not a substitute for large, long-term human clinical trials

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TB-500 injection: Given TB-500's systemic distribution regardless of injection site, most protocols use simple subcutaneous abdominal injection

The Phase 2b OPTIONS trial 536 obese subjects, randomized to receive 0.25, 0.5, or 1 mg/day oral AOD-9604 or placebo over 24 weeks failed to demonstrate statistically significant weight loss at any dose tested