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Several peripheral and central mechanisms are believed to be involved, including altered gut hormone secretion, decrease in energy expenditure following weight loss, and psychological processes associated with the food reward system
Funding This research received no specific grant from funding agencies in the public, commercial, or not-for-profit sectors
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Daily oral L-carnosine (500 mg, p.o., daily for 3 months) significantly ameliorated the pathophysiological triad of inflammation, oxidative stress, and apoptosis in patients receiving FOLFOX-6 regimen (OXA + 5FU + leucovorin), for instance, decreasing the molondialdehyde (MDA) level (51.8%), nuclear factor-B (NF-B) (27%), and TNF- (36.6%), while increasing Nrf-2 (38.7%) (Yehia et al., 2019)
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