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doi: 10.2337/dc13-0863

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It occurs when excess fat builds up in the liver, which may interfere with the organs ability to: Remove toxins from the bloodstream Digest food Store and release energy Participants in early retatrutide studies also showed improvements in hemoglobin A1c (a measure of long-term blood sugar control), blood pressure, and LDL cholesterol levels as they lost weight.[7] What Are Retatrutide's Side Effects or Risks