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A prescriber may decide if 5mg is appropriate based on your stability on a higher Wegovy dose, but 2.5mg remains the default

Both approaches are used by researchers seeking sustained AMPK activation throughout the day rather than pulsatile peaks around individual doses

FAS = full analysis set, GLP-1 = glucagon-like peptide-1, TBW = total body weight

12.2 Pharmacodynamics The pharmacodynamic evaluations described below were in patients with type 2 diabetes mellitus who received once weekly subcutaneous injections of placebo or semaglutide injection over 12 weeks (semaglutide injection-treated patients were started on lower dosages and then titrated up to 1 mg once weekly)

A second unknown is safety