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The phase 2 trial published in The New England Journal of Medicine in 2023 enrolled adults with obesity without type 2 diabetes and demonstrated dose-dependent weight loss of up to 24.2% of body weight at the highest dose over 48 weeks results that attracted considerable scientific and media attention

Managing them has always required a combination of diet, exercise, and medication

In One Sentence: Retatrutide, also known as Triple G, is a once-weekly injectable medication currently being researched for weight loss and Type 2 diabetes, showing promising results in early studies by targeting multiple metabolic pathways involved in appetite control and fat metabolism

Critically it provided the first evidence of the 'posttranslational processing of a polypeptide precursor into the mature functional form of the hormone by specialized proteolytic enzymes'

10.1111/adb.13211 19 FortinS