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While there is no specific FDA deferral for GLP-1/GIP agents, regulations require that donors be in good health and that medications do not pose risks to recipients or compromise donor safety during the collection process

What FDA Scientists Found and Why They Said No Before the meeting, FDA career scientists completed a systematic review of all seven peptides under the agency's four-part balancing test under 21 CFR 216.23(c): physical and chemical characterization, historical compounding use, evidence of effectiveness, and safety

Compounded semaglutide and tirzepatide

However, tirzepatide also causes delayed gastric emptying and can produce similar GI symptoms

Both toxins significantly altered sulfur metabolism, as determined by HPLC-MS/MS