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GLP-1R expressed in the nucleus tractus solitarius signals to suppress appetite, delay gastric emptying and reduce body weight, and this is proposed to be mediated through PKA, decreasing phosphorylation of AMPK (22, 89, 110)

The induced structural changes are believed to facilitate the activation of G-proteins, signaling proteins theorized to reside on the cell's interior side of the GHRH receptor

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