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Reactive oxygen species (ROS) have an important role in the homeostasis of the vascular wall

Common side effects include: Gastrointestinal issues: Nausea, vomiting, constipation, and abdominal pain Injection site reactions: Redness, swelling, and pain Systemic issues: Fatigue, indigestion, heartburn, belching, and hair loss More severe side effects include: Thyroid problems: Medullary thyroid cancer and pancreatitis with severe, persistent abdominal pain Gallbladder problems with symptoms such as upper abdominal pain, fever, jaundice, or clay-colored stools Increased risk of hypoglycemia with symptoms such as dizziness, sweating, confusion, and shakiness Severe vomiting that leads to dehydration and kidney problems Mental health concerns such as depression and suicidal thoughts Vision changes from rapid changes in blood glucose levels Some patients should not use Zepbound, such as those who have or are at risk for medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

The Medicines and Healthcare products Regulatory Agency (MHRA) regulates these medications, and NICE provides guidance on their use within the NHS

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Because terminology, peptide form, assay design, and reporting quality vary across the historical literature, study conclusions should remain tied to the exact sequence, disulfide configuration, counterion or salt form, formulation, species, route, exposure period, and endpoint used