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& Lemon, S
The resulting supernatants were diluted in a 5 times volume, and the dilutions were used in the assay
Even with that context, this result does not meet the standard we want for release
FOXO4-DRI enters senescent cells and competitively binds to p53 through its modified peptide sequence, displacing endogenous FOXO4 and freeing p53 to activate cell death pathways including BAX and PUMA
A highly glycolytic or pro-angiogenic product may worsen edema, vascular permeability, or ectopic tissue responses
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