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Male SD rats were administered a single IM injection of blank solvent (excipient), and biological samples, including whole blood, plasma, urine, feces, and tissues, were collected for background control

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Gradual dose escalation of GLP-1 medications, following FDA-approved titration schedules, helps minimize gastrointestinal side effects that may indirectly contribute to muscle symptoms through reduced intake and activity

Pharmacological management requires careful consideration in patients with diabetes: NSAIDs (such as ibuprofen or naproxen) are first-line when medication is needed and not contraindicated