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For example, the use of oral forms of estrogen can be prothrombotic whereas the use of transdermal hormones does not seem to present with the same complication

Historically, covering only these indications would limit the availability of rebates, which discouraged some employers from offering coverage for newer indications unless they also covered the broader obesity indication

the paper in Diabetes and Metabolism Journal, July 2026 GLP-1 receptor agonists such as semaglutide have transformed obesity treatment by inducing substantial weight loss and improving metabolic health

Some people use lower doses during breaks rather than complete discontinuation, but this strategy lacks clinical validation

The study enrolled 40 participants and is now complete, though the data have not yet been reported